Time 4 GDA – Glucose Disposal Agent

Time 4 GDA - Glucose Disposal Agent

Take 2 Capsules 3 times daily. This product will be more effective if taken 30 minutes before main meals and spread out during the day i.e. breakfast, lunch and dinner.

Do not exceed the stated dose.

Click on individual ingredients for further info:

Berberine HCI, Sutherlandia Frutescens, Vegetable Capsule, Kalahari Bitter Melon (4:1 Extract), Gymnema Sylvestre Extract (25% Gymnemic Acid) (4:1 Extract), Black Pepper (95% Piperine), Cinnamon Bark Extract (30% Polyphenols) (30:1 Extract), Anti-Caking Agents: (Silicon Dioxide, Magnesium Stearate), Chromium Picolinate.

Made in a facility that handles milk, egg and soya.
Time 4 GDA is Vegan Friendly.
Soy Free.
Lactose Free.
Gluten Free.
GMO Free.
We do not use Carboxymethylcellulose in any of our products.

DISCLAIMER

Use only in conjunction with a varied diet. Should not be used as a sole source of nutrition. Discontinue use and seek medical attention in the case of adverse reactions. If you are under medical supervision, pregnant, planning pregnancy, breastfeeding or suffer from food allergies seek professional advice before taking supplements.

STORAGE INSTRUCTIONS

Store out of direct sunlight in a cool dry place and keep out of reach of young children.

UK Mainland customers receive FREE delivery on orders over £35. Orders under £35 will incur a £6.50 delivery charge.

There is a £10.00 surcharge for delivery to Northern Ireland, Isles of Scilly, Scottish Highlands & Scottish Islands.

All orders received before 3pm Monday – Friday (except Bank Holidays) will be sent out the same day for next-day delivery. Orders received after 3pm on Friday will be sent out on Monday for delivery on Tuesday (except Bank holidays).

We use DPD for the majority of our deliveries and if your order has been sent by DPD you will receive a notification from them when your order has been processed.

Please ensure you supply us with a mobile number and email address as DPD will contact you with tracking details.

The best way to track your parcel is by using DPD’s app which can be downloaded below.

Please download the DPD App, Android Click Here

Please download the DPD App, iOS Click here

All delivery times stated are estimated, and we make every effort to deliver goods within the stated timescale. However delays are occasionally inevitable due to unforeseen circumstances.

Time 4 Nutrition shall be under no liability for any delay or failure to deliver goods within the estimated timescale.

When receiving goods you must count the items and check for damage and then sign and print your name to confirm you have received the whole order in good condition.

It is stated on the couriers delivery note the number of boxes you should receive. If the number of boxes you have received does not match the number stated on the delivery note you must note the number of boxes received on the delivery note by your signature.

Any damage to the packaging must be noted on the delivery note next to your signature. The words “unexamined” or “unchecked” will not be acceptable.

Any shortages or damages must be reported to Time 4 Nutrition within 48 hours of delivery.

QUESTION

I am interested in purchasing your Time 4 GDA Glucose Disposal Agent product, however when looking at the ingredients I noticed that it does not contain Alpha Lipoic Acid, which I have been told is a key ingredient in a Glucose Disposal Agent.

Is there a reason it does not contain Alpha Lipoic Acid?

REPLY

Thank you for dropping us a line about Time 4 GDA Glucose Disposal Agent. My name is Brian Batcheldor, I consult to Time 4 Nutrition on all matters relating to research and development. In the formulation of a Glucose Disposal Agent formula, there are a few questions we have to ask of ingredients, but there are at least as many hurdles to clear in getting a finished product out there. Of course, number one will always be safety, closely followed by efficacy. Financial viability and sustainability then enter the equation, this is where the wheels start to fall off for Alpha Lipoic Acid.

ALA can be a great addition, as you likely know, there is good research on its ability as a Glucose Disposal Agent, both in vitro and in vivo in animals and humans with type 2 diabetes. I believe it has a lot to offer in various forms of neuropathy and not just with diabetics, it’s a serious tool with early stage ischemic stroke victims too. However, the ALA used in most studies and that which we come across in the supplement industry are quite different materials. ALA found in most supplements is supposedly a blend of two isomers, R and S, it is supposed to be a 50:50 blend. This really matters because only the R isomer is the natural form as it exists in the body and with good bioavailability, it is also the isomer responsible for the reported antioxidant effects of ALA. It is the only form that functions as a cofactor in mitochondrial energy production. Unfortunately, R Lipoic acid is physically unstable at just above room temperature once separated from the S isomer, it deteriorates pretty rapidly during the supplement manufacturing process/encapsulation/tabletting, and you end up with reduced GI absorption and a bioavailability of less than 10%. Even when you blend the R and S (a by-product of chemical synthesis of the racemic ALA isomers, poor GI absorption means that as little as 20% reaches the plasma.

In 25 plus years in the industry, most of the material I see coming in from China is certainly a far cry from a 50:50 blend (normally around 80:20 S to R). The material used in most studies is intravenous racemic ALA or proprietary stabilized R isomer, both of which yield 20-40 times higher plasma levels. So why didn’t we seek out proprietary stabilized R Lipoic Acid? First would be safety, there are adverse reports of hypoglycemia from prediabetic and diabetic (Type 2) users, but also from those using in combination with other nutraceutical ingredients (e.g. chromium). There are also controls on this ingredient in countries like Canada, consideration is going on within the EU. However, when we considered efficacy, then our current blend certainly stood the test, as we looked at the multiple mechanisms involved in improving glucose disposal (e.g. reducing inflammation, AMPK, PKB/AKT, GLUT4 agonism, etc) and reviewed available scientifically validated ingredients for the purpose, producing a formula we feel ticked the box for most athletes and not simply those with reduced insulin sensitivity. I hope this has provided an answer for you, but please do not hesitate dropping me a line should you have any further questions.

Brian Batcheldor MSc, R & D Time 4 Nutrition.