Immunomodulating and antistress activity of ecdysterone and turkesterone under immobilization-induced stress conditions in mice. 

Shakhmurova, G.A., Syrov, V.N. & Khushbaktova, Z.A.

Abstract

The phytoecdysteroids ecdysterone and turkesterone isolated from Rhaponticum integrifolium and Ajuga turkestanica herbs, respectively, increase the adaptation capacity of mice under immobilization-induced stress conditions. These compounds prevent involution of the thymicolymphatic system, decrease trophic disorders in gastric mucosa, prevent an increase in the weight of adrenal glands and a decrease in them of the content of ascorbic acid and cholesterol (to a much greater degree than does T-activin), and stimulate immunogenesis in animals with experimental immune deficiency developed on the background of immobilization-induced stress.