2. Eur J Nutr. 2012 Oct;51(7):791-9.

Coenzyme Q(10) supplementation ameliorates inflammatory signaling and oxidative stress associated with strenuous exercise.

Díaz-Castro J¹, Guisado R, Kajarabille N, García C, Guisado IM, de Teresa C, Ochoa JJ.

 

Abstract

BACKGROUND:

Exhausting exercise induces muscle damage associated with high production of free radicals and pro-inflammatory mediators.

AIM:

The objective of this study was to determine for the first time and simultaneously whether oral coenzyme Q(10) (CoQ(10)) supplementation can prevent over-expression of inflammatory mediators and oxidative stress associated with strenuous exercise.

METHODS:

The participants were classified in two groups: CoQ(10) group (CG) and placebo group (PG). The physical test consisted in a constant run (50 km) that combined several degrees of high effort (mountain run and ultra-endurance), in permanent climbing.

RESULTS:

Exercise was associated with an increase in TNF-α, IL-6, 8-hydroxy-2′-deoxyguanosine (8-OHdG), and isoprostane levels, revealing the degree of inflammation and oxidative stress induced. Oral supplementation of CoQ(10) during exercise was efficient reducing oxidative stress (decreased membrane hydroperoxides, 8-OHdG and isoprostanes generation, increased catalase, and total antioxidant status), which would lead to the maintenance of the cell integrity. Data obtained also indicate that CoQ(10) prevents over-expression of TNF-α after exercise, together with an increase in sTNF-RII that limits the pro-inflammatory actions of TNF. Moreover, CoQ(10) supplementation reduced creatinine production.

CONCLUSIONS:

CoQ(10) supplementation before strenuous exercise decreases the oxidative stress and modulates the inflammatory signalling, reducing the subsequent muscle damage.